association between hla-dqb1 alleles and ham/tsp patients in khorasan province
نویسندگان
چکیده
objective(s): htlvi-1 is the first human retrovirus with limited endemic regions in the world. the epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in htlv-i-associated diseases. among the genes are involved in htlv-i infection, the role of human leukocytes antigen (hla) have been studied in different population. in the present study we examined the association between hla-dqb1 alleles and htlv-i infection in ham/tsp patients, htlv-i carriers and healthy controls in north east of iran, mashhad. materials and methods:the blood samples of 16 patients with ham/tsp, 20 htlv-1 carriers, and 30 healthy individuals were taken and dna was extracted by salting out method. hla-dqb1 typing was performed using pcr-ssp method and the frequency of hla-dqb1 alleles were compared by fischer exact test. results:there was a significant difference between ham/tsp patients and healthy controls in the frequency of hla-dqb1*07 (p=0.004, rr=7). furthermore, we found that possession of hla- dqb1*02 or hla-dqb1*05 increased the risk of disease 1.5 times. conclusion: the data presented here suggest that both hla-dqb1*07 and hla-dqb1*06 are associated with disease development.
منابع مشابه
Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province
Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the pre...
متن کاملAssociation between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province
OBJECTIVES HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the present...
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۷، شماره ۱۰، صفحات ۷۹۸-۸۰۱
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